Tissue engineering has developed greatly in the past 10 years and aims to restore, maintain or improve tissue functions that are defective or have been lost due to different pathological conditions, either by developing biological substitutes or by reconstructing tissues. Scaffolds play a unique role in tissue regeneration and repair and have been used for engineering tissues such as bone, cartilage, ligaments, skin, vascular tissues, neural tissues and skeletal muscles and as a vehicle for the controlled release of drugs, proteins ​​and DNA. In scaffold design and application, polymers have been widely used as biomaterials for the fabrication of medical devices and scaffolds for tissue engineering. Synthetic polymers represent the largest group of biodegradable polymers and can be produced under controlled conditions. This essay aims to accomplish two tasks on this exciting research topic. First, it summarizes the three most commonly used synthetic polymers in tissue engineering and the other two synthetic polymers with different mechanical and physical properties. These include poly(glycolic acid) (PGA), poly(lactic acid) (PLA), polyanhydrides, polycaprlactone (PCL), and poly(lactide-co-glycolide) (PLGA). Secondly, it illustrates four different methodologies or techniques adopted for the fabrication of polymer scaffolds. These include the solvent melting and particulate leaching method, the gas foaming method, thermally induced phase separation, and rapid prototyping. Both the advantages and limitations associated with each method are illustrated and compared qualitatively. Polyglycolide (Figure 1) is a thermoplastic polymer that is the simplest aliphatic polyester with a high crystallinity of 46 to 50% and high tensile strength......paper medium.... ...the high tensile modulus that can be used in bone internal fixation and orthopedic fixation devices. It is essential to note that PLA can be used in injectable form, to treat the patient suffering from immunodeficiency virus. PLGA copolymer has shorter degradation time than monomer, can be applied in drug delivery vehicle, suture anchors and orthopedic implants. PCL modulus is close to zero, cannot be used in any mechanical support application. Meanwhile, due to the long-term zero order release, PCL can be applied in the contraceptive device. Finally, polyanhydride can be called the safest polymer. The degradation products of polyanhydride are biocompatible and can be taken into the human body without any side effects. It is essential to note that the rate of degradation is based on the following factors: copolymer ratio, crystallinity, molecular weight, porosity and structure.