Hyaluronic acid is a naturally occurring non-sulfated polysaccharide of the glycosaminoglycan family of the extracellular matrix of connective tissue, synovial fluid and other tissues. 1,2 HA synthesis occurs in the cell membranes of most cells in the body, then secreted into the extracellular space. HA also produced by fibroblasts in the presence of endotoxins. It is a key component in the wound healing process in both calcified and non-calcified tissues. HA preparations used as fillers have been produced from bacterial or animal sources and their clinical effect typically lasts 6-12 months, HYADENT BG is a new biodegradable tissue gel with transparent hyaluronic acid not of animal origin.1 Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Many in vitro and animal studies have reported encouraging results with HA, particularly with its positive effects on fibroblasts, bone regeneration, and wound healing.3, 4 HA acts as an anti-inflammatory5,6 and as a possible therapeutic option in osteoarthritis7 and as a soft tissue filler.8 In dentistry, HA has shown a positive effect on plaque-induced gingivitis with regards to plaque reduction and sulcus bleeding patients.9,10 Only In a few studies, HA has been applied in addition to SRP in the non-surgical treatment of periodontitis. Johannsen et al.11 demonstrated that after subgingival application of 0.8% HA gel immediately after SRP and 7 days later, bleeding on probing (BOP) and probing depth (PD) were significantly reduced . However, Xu Y et al.12 reported no influence of the application of 0.2% HA gel after SRP on clinical parameters after 6 and 12 weeks in patients with chronic periodontitis. Topically applied high-molecular-weight HyA has also been shown to stimulate mesenchymal and muscle cell differentiation and migration in vivo.13 A recent clinical study14 demonstrated that osteoconduction was more efficient in HA-mixed autologous bone grafting than to autologous bone grafting alone. A Medline search including the keywords “periodontitis,” “extraction socket healing,” and “hyaluronic acid” showed insufficient results. Please note: this is just an example. Get a custom paper from our expert writers now. Get custom essayThe beneficial effect of a gel containing hyaluronic acid as an adjunct to non-surgical periodontal therapy in plaque-induced gingivitis is reported by clinical and paraclinical variables.15. However, the possible effect of HA in the treatment of periodontal diseases is inconclusive due to the wide variability in the available literature.16 Therefore, the present study aimed to clinically and radiographically evaluate the healing of the extraction socket using HA and evaluate the effect of HA with scaling and root planing in the periodontal treatment of patients with moderate to advanced chronic periodontitis and comparison with simple scaling and root planing.