Sepsis is defined as a systemic inflammatory response caused by a viral, bacterial or fungal infectious process (Holling, 2011). Evaluation of a patient and initiation of treatment for sepsis is based on the identification of several factors including the infectious source, administration of antibiotics, and fluid replacement (Bailey, 2013). Because time is of the essence, any delay in identifying patients with sepsis will have a negative effect on patient outcomes. Many studies have concluded that every hour of delay in treatment mortality increases by 7% (Bailey, 2013). Within this assignment I will briefly discuss previous practice and recent practice including the sepsis-based study. I will show what allowed the practice to change and use the two comparisons between current practice and best practice. Sepsis is a life-threatening health condition and if not treated early can lead to shock, multi-organ failure and death (Ho, 2012). The main study on which the worldwide practice was based is the Surviving Sepsis Campaign. The Surviving Sepsis campaign was developed to create evidence-based management guidelines. The Surviving Sepsis campaign complemented this by using an educational program to implement the guidelines by integrating their recommendations into resuscitation and management packages (Marik, 2011). The first Surviving Sepsis campaign guidelines were published in Critical Care Medicine in 2004 with an updated version published in 2008, but the core recommendations have remained largely unchanged (Ahrens, 2011). Within the Surviving Sepsis campaign guidelines and packages have been introduced which can be used as the basis of a sepsis performance improvement programme. The Guidelines were based on a six-point action plan (…… half of the document…… 0% realize it is a major cause of death (World Sepsis Day, 2012). If sepsis can be Diagnosed early and managed appropriately, it is possible to save lives. A key factor in the lack of public awareness about sepsis is that there is still a lot of confusion about what sepsis really is. Everyone recognizes this, but sepsis can be a problem. vague term, indicative of a blood infection (World Sepsis Day, 2012 In conclusion, research and updating of current studies have a great influence in creating new evidence-based guidelines in the treatment of sepsis and revision of the latest guidelines will provide safer care for patients The path to reducing mortality from sepsis begins with early recognition by nursing and medical staff and also with educating patients before they even present..