Applied Pharmacology Morphine is excreted through the urinary system and the biliary system. In the urinary system, the drug is excreted based on the amount of urine excreted by an individual (Armstrong & Cozza 2003). After being consumed by the liver, morphine passes into the bloodstream, from where it reaches the kidneys for excretion. The drug is then absorbed into the urinary system and directed to the bladder for excretion. The drug is metabolized in the liver and then passed to the kidneys. After ingestion, more than 60% of the drug is converted to M3G, a compound that makes it highly effective in the central nervous system. The reaction of morphine in the body is as shown in the following diagram. Morphine alters the operations of interleukin and this normally causes adverse effects on the host. When morphine attacks the central and sympathetic nervous systems, many cellular and molecular activities are altered (Chahl 1996). One of the functions that are altered is stimulus detection. Pain and other stimuli are not detected once the drug is taken. In case a patient suffers from asthma and leukemia, it is advisable not to administer the drug (Jiang & Ma 2007). Leukemia is a blood-associated disease and the effects of morphine on the blood are immense, as the drug attacks the organs that deal with blood circulation (Health Grades 2011). Morphine can therefore be a very dangerous drug to associate with leukemia as it can cause a serious blood clot and ultimately death. Asthma is also another disease that should never be combined with morphine. Advair Diskus is one of the drugs that interact unfavorably with morphine (Stoelting 1999). The drug is used in the treatment of asthma and when it reacts with morphine, the patient should be treated for pain. This is because both drugs stimulate the respiratory organs and increase the heart rate (Bartnik, Hovda & Lee 2007). Flexeril may also cause adverse effects when taken in combination with morphine. This is because the drug is a central nervous system and respiratory system depressant (Department of Health 2011). In addition to these two drugs, Lexapro should never be taken with morphine as it may increase reactions and depressant effects on the central nervous system and respiratory system. The consequences are total inactivity of the body and if taken in overdose coma or death can occur (Martin, Rosenthal & Fiskum 2005).