Disease Summary Huntington's disease is of great concern because it is a genetic disease that affects many people around the world. Huntington's disease is described by Wider and Luthi-Carter (2006) as the most common hereditary neurodegenerative disease in humans, affecting two to eight per 100,000 inhabitants of Western countries. Huntington's disease also has a slow onset, with an average age of onset around 40 years (Wider & Luthi-Carter, 2006). Wider and Luthi-Carter (2006) note that the cause of this disease is a mutation in the huntingtin gene, which can be characterized by distinct symptoms. Chorea, from the Greek "to dance", is the main distinguishing feature of this mutation and is described by Wider and Luthi-Carter (2006) as rapid involuntary movements manifesting as lifting of the eyelids, rocking of the head, facial grimacing and twitching of the face. arts. Chorea is also evident in the way one walks, causing the individual to move in a zigzag pattern and appear to become unbalanced due to involuntary movements (Wider & Luthi-Carter, 2006). The duration of the disease is between ten and thirty years and is often noted in the early stages by symptoms such as attention disorders, personality changes and alterations in motor control (Wider & Luthi-Carter, 2006). Although Huntington's disease is caused by a mutation, research is still focused on its pathogenesis to gain a better understanding of the disease. Research conducted by Wider and Luthi-Carter (2006) shows that the main pathological causes of Huntington's disease are atrophy and gliosis of the caudate nucleus and putamen, which become evident and statistically significant approximately ten years before the onset of the disease. illness. The research carried out by Wider and Luthi-Carter (2006) also highlights a significant loss of GA......mid article......2013) and chose to use only male mice to avoid estrus of females cycle. The use of female mice would improve this study because females certainly differ biologically from males and may therefore experience different effects of Huntington's disease. The knowledge gained as a result of these differences may be useful in the treatment of Huntington's disease in male and female patients. Works Cited Wider, C., & Lüthi-Carter, R. (2006). Huntington's disease: clinical and etiological aspects. Swiss Archives for Neurology and Psychiatry, 157(8), 378-383. Retrieved from http://search.proquest.com.er.lib.k-state.edu/docview/621626856?accountid=11789Abada, Y. K., Schreiber, R., & Ellenbroek, B. (2013). Motor, emotional, and cognitive deficits in adult BACHD mice: a model for Huntington's disease. Behavioral Brain Research, 238, 243-251. doi:http://dx.doi.org/10.1016/j.bbr.2012.10.039