Objectives: To evaluate the neuroprotective effect of curcumin (turmeric) aqueous extract in scopolamine-induced cognitive impairment in mice. Compare cognitive impairment curcumin (turmeric) with the stranded drug (Donepezil 50 µg/kg). Methods: After obtaining Institutional Ethics Committee approval, Swiss albino mice (18-25 g) of both sexes were randomly divided into 4 groups of 6 animals each. Each animal received scopolamine (0.05 mg/kg) for 13 days. On day 14 each animal was checked for cognitive impairment using the Elevated Plus Maze (EPM). The dried curcumin (turmeric) powder was boiled with distilled water, cooled, filtered, placed on a heating plate for complete evaporation, finally weighed and stored. The control group, test group and standard drug group received saline, curcumin (turmeric) extract (150 and 300 mg/kg), donepezil (50 µg/kg) via oral feeding, respectively. The neuroprotective effect was evaluated using Elevated Plus Maze (EPM) in mice. Results: In EPM (Elevated Plus Maze) models, implies that curcumin (turmeric) 150 mg/kg (group III) and 300 mg/kg (group IV) significantly ...