“The reduction in lean muscle mass by approximately 20% and the decrease in total body water by 10-15% imply changes in the absorption of many drugs” (Woo & Wynne, 2011 , p. 1424). This may result in higher serum concentrations of drugs at normal dosages. Body fat stores increase and fat-soluble drugs have a “greater tendency to accumulate in adipose tissue, resulting in lower serum concentrations and prolonged duration of action due to a longer half-life” (Woo & Wynne, 2011, p. 1424). Decreased albumin levels may lead to higher levels of unbound drug available for metabolism and tissue perfusion, allowing freer circulation